TRIM28

Information TRIM28

Description

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112). {ECO:0000250|UniProtKB:Q13263, ECO:0000269|PubMed:20164836, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:22110054, ECO:0000269|PubMed:27658112, ECO:0000269|PubMed:9742105}.(Source UnitProtKB).

Full Name

tripartite motif-containing 28

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
17
Biotypes
6
Peaks
341,572
Non-redundant peaks
256,165

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
21849
Official Gene Name
Trim28
JASPAR
MGI
MGI:109274
Ensembl
ENSMUSG00000005566
UniProt
Q62318
Genevisible
Q62318
RefSeq
NM_011588
Aliases
AA408787; KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta
All peaks TRIM28
Download BED file
Non redundant peaks TRIM28
Download BED file
SEQUENCES TRIM28
Download FASTA file
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Datasets Table for TRIM28

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TRIM28 E14 GEO Mus musculus GSE70799 13,267
TRIM28 Th17 GEO Mus musculus GSE98427 4,916
TRIM28 J1 GEO Mus musculus GSE58323 64,851
TRIM28 liver-hepatoma GEO Mus musculus GSE87734 30,773
TRIM28 mESC KO GEO Mus musculus GSE115286 311
TRIM28 mESC KO GEO Mus musculus GSE41903 22,806
TRIM28 mESC GFP_KO GEO Mus musculus GSE115286 22,072
TRIM28 mESC GEO Mus musculus GSE123942 105,470
TRIM28 mESC KO GEO Mus musculus GSE77440 14,097
TRIM28 MEF GEO Mus musculus GSE86391 207
TRIM28 mESC GEO Mus musculus GSE125673 62,618
TRIM28 mESC GEO Mus musculus GSE41903 2,566
TRIM28 mESC GFP GEO Mus musculus GSE115286 30,245
TRIM28 mESC GEO Mus musculus GSE115286 874
TRIM28 mESC GEO Mus musculus GSE87734 49,879
TRIM28 mESC KO GEO Mus musculus GSE123942 373
TRIM28 mESC BJ1 GEO Mus musculus GSE74757 21,407
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks