TRIM28
Information TRIM28
- Description
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112). {ECO:0000250|UniProtKB:Q13263, ECO:0000269|PubMed:20164836, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:22110054, ECO:0000269|PubMed:27658112, ECO:0000269|PubMed:9742105}.(Source UnitProtKB).
- Full Name
tripartite motif-containing 28
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 17
- Biotypes
- 6
- Peaks
- 341,572
- Non-redundant peaks
- 256,165
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 21849
- Official Gene Name
- Trim28
- JASPAR
- MGI
- MGI:109274
- Ensembl
- ENSMUSG00000005566
- UniProt
- Q62318
- Genevisible
- Q62318
- RefSeq
- NM_011588
- Aliases
- AA408787; KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta
Datasets Table for TRIM28
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
TRIM28 | E14 | GEO | Mus musculus | GSE70799 | 13,267 | |||
TRIM28 | Th17 | GEO | Mus musculus | GSE98427 | 4,916 | |||
TRIM28 | J1 | GEO | Mus musculus | GSE58323 | 64,851 | |||
TRIM28 | liver-hepatoma | GEO | Mus musculus | GSE87734 | 30,773 | |||
TRIM28 | mESC | KO | GEO | Mus musculus | GSE115286 | 311 | ||
TRIM28 | mESC | KO | GEO | Mus musculus | GSE41903 | 22,806 | ||
TRIM28 | mESC | GFP_KO | GEO | Mus musculus | GSE115286 | 22,072 | ||
TRIM28 | mESC | GEO | Mus musculus | GSE123942 | 105,470 | |||
TRIM28 | mESC | KO | GEO | Mus musculus | GSE77440 | 14,097 | ||
TRIM28 | MEF | GEO | Mus musculus | GSE86391 | 207 | |||
TRIM28 | mESC | GEO | Mus musculus | GSE125673 | 62,618 | |||
TRIM28 | mESC | GEO | Mus musculus | GSE41903 | 2,566 | |||
TRIM28 | mESC | GFP | GEO | Mus musculus | GSE115286 | 30,245 | ||
TRIM28 | mESC | GEO | Mus musculus | GSE115286 | 874 | |||
TRIM28 | mESC | GEO | Mus musculus | GSE87734 | 49,879 | |||
TRIM28 | mESC | KO | GEO | Mus musculus | GSE123942 | 373 | ||
TRIM28 | mESC | BJ1 | GEO | Mus musculus | GSE74757 | 21,407 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |