TWIST1
Information TWIST1
- Description
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]
- Full Name
twist family bHLH transcription factor 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 6
- Biotypes
- 3
- Peaks
- 202,506
- Non-redundant peaks
- 76,099
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- Tal-related factors
- Sub Familly
- Twist-like factors
Source TFClass
Datasets Table for TWIST1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TWIST1 | BE2C | GEO | Homo sapiens | GSE80151 | 49,102 | |||
| TWIST1 | SHEP-21N | 24h | GEO | Homo sapiens | GSE80151 | 21,869 | ||
| TWIST1 | SHEP-21N | GEO | Homo sapiens | GSE80151 | 52,905 | |||
| TWIST1 | SHEP-21N | DOX_24H | GEO | Homo sapiens | GSE80151 | 3,061 | ||
| TWIST1 | SHEP-21N | DOX_0H | GEO | Homo sapiens | GSE80151 | 25,275 | ||
| TWIST1 | SK-N-BE2-C | GEO | Homo sapiens | GSE80151 | 50,294 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |