TWIST2
Information TWIST2
- Description
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity). {ECO:0000250, ECO:0000269|PubMed:11809751, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:7589808}.
- Full Name
twist basic helix-loop-helix transcription factor 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 73,532
- Non-redundant peaks
- 71,807
TF Classification
- Familly
- Basic helix-loop-helix factors (bHLH)
- Sub Familly
- Tal-related factors
Source JASPAR
External IDs
- NCBI Gene
- 13345
- Official Gene Name
- Twist2
- JASPAR
- MA0633.1
- MGI
- MGI:104685
- Ensembl
- ENSMUSG00000007805
- UniProt
- Q9D030
- Genevisible
- Q9D030
- RefSeq
- NM_007855
- Aliases
- Dermo1; bHLHa39
Datasets Table for TWIST2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TWIST2 | primary-myoblast | GM_GFP | GEO | Mus musculus | GSE127998 | 2,516 | ||
| TWIST2 | primary-myoblast | DM_GFP | GEO | Mus musculus | GSE127998 | 9,873 | ||
| TWIST2 | primary-myoblast | DM_TW2 | GEO | Mus musculus | GSE127998 | 61,143 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |