USF1

Information USF1

Description

This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Full Name

upstream transcription factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
5
Biotypes
5
Peaks
80,305
Non-redundant peaks
44,565

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
22278
Official Gene Name
Usf1
JASPAR
MGI
MGI:99542
Ensembl
ENSMUSG00000026641
UniProt
Q61069
Genevisible
Q61069
RefSeq
NM_009480
Aliases
bHLHb11; upstream stimulatory factor
All peaks USF1
Download BED file
Non redundant peaks USF1
Download BED file
SEQUENCES USF1
Download FASTA file
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Datasets Table for USF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
USF1 CH12-LX ENCODE Mus musculus ENCSR973SOG 8,560
USF1 myocyte ENCODE Mus musculus ENCSR000AIE 21,028
USF1 mESC-E14 GEO Mus musculus GSE122715 12,942
USF1 MEL ENCODE Mus musculus ENCSR705HGT 17,603
USF1 C2C12 ENCODE Mus musculus ENCSR000AIQ 20,172
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks