WDR5
Information WDR5
- Description
Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). {ECO:0000250|UniProtKB:P61964, ECO:0000269|PubMed:11551928}.(Source UnitProtKB).
- Full Name
WD repeat domain 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 12
- Biotypes
- 8
- Peaks
- 171,040
- Non-redundant peaks
- 98,097
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 140858
- Official Gene Name
- Wdr5
- JASPAR
- MGI
- MGI:2155884
- Ensembl
- ENSMUSG00000026917
- UniProt
- P61965
- Genevisible
- P61965
- RefSeq
- NM_080848
- Aliases
- 2410008O07Rik; Big-3; Bmp2-induced gene
Datasets Table for WDR5
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| WDR5 | C2C12 | MB | GEO | Mus musculus | GSE50590 | 10,623 | ||
| WDR5 | B-cell | resting | GEO | Mus musculus | GSE82144 | 17,654 | ||
| WDR5 | mESC | GEO | Mus musculus | GSE22934 | 4,627 | |||
| WDR5 | mESC | FL | GEO | Mus musculus | GSE22934 | 13,404 | ||
| WDR5 | bone-marrow | EtOH | GEO | Mus musculus | GSE68821 | 5,330 | ||
| WDR5 | mESC-E14 | GEO | Mus musculus | GSE122715 | 12,776 | |||
| WDR5 | MC38 | GEO | Mus musculus | GSE136451 | 16,881 | |||
| WDR5 | bone-marrow | 4OHT | GEO | Mus musculus | GSE68821 | 5,007 | ||
| WDR5 | 3T3 | GEO | Mus musculus | GSE136451 | 14,269 | |||
| WDR5 | B-cell | activated | GEO | Mus musculus | GSE82144 | 40,320 | ||
| WDR5 | MLL-AF9 | DMSO | GEO | Mus musculus | GSE68821 | 16,628 | ||
| WDR5 | MLL-AF9 | MM-401 | GEO | Mus musculus | GSE68821 | 13,521 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |