Xbp1

The gene X box binding protein-1 is referred to in FlyBase by the symbol DmelXbp1 (CG9415, FBgn0021872). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (all unique). Gene sequence location is 2R:21143545..21145750. Its molecular function is described by: RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: intestinal stem cell homeostasis; regulation of translation in response to endoplasmic reticulum stress; response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; endoplasmic reticulum unfolded protein response. 29 alleles are reported. The phenotypes of these alleles manifest in: adult thoracic segment; tracheolar cell; adult optic lobe neuron; mesothoracic segment; wing. The phenotypic classes of alleles include: phenotype; lethal - all die before end of pupal stage; cell growth defective; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

X box binding protein-1

Source FlyBase

Drosophila melanogaster [tax_id: 7227]

dm6