YY1

Information YY1

Description

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'-CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double-strand break repair. Plays a role in regulating enhancer activation (By similarity). {ECO:0000250|UniProtKB:P25490, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:19786570}.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000250}.(Source UnitProtKB).

Full Name

YY1 transcription factor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
27
Biotypes
9
Peaks
699,992
Non-redundant peaks
193,160

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
22632
Official Gene Name
Yy1
JASPAR
MGI
MGI:99150
Ensembl
ENSMUSG00000021264
UniProt
Q00899
Genevisible
Q00899
RefSeq
NM_009537
Aliases
NF-E1; UCRBP transcription factor; YY-1; Yin Yang 1; delta transcription factor
All peaks YY1
Download BED file
Non redundant peaks YY1
Download BED file
SEQUENCES YY1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for YY1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
YY1 pre-B-cell GEO Mus musculus GSE73531 10,811
YY1 intestine GEO Mus musculus GSE53502 284
YY1 C2C12 sc GEO Mus musculus GSE45875 1,984
YY1 follicular-B-cell GEO Mus musculus GSE73531 3,897
YY1 mESC EpiLSC GEO Mus musculus GSE92407 33,497
YY1 mESC GEO Mus musculus GSE140546 35,891
YY1 mESC shLuc GEO Mus musculus GSE68195 41,438
YY1 mESC 2i GEO Mus musculus GSE92407 22,635
YY1 mESC serum GEO Mus musculus GSE92407 34,148
YY1 mESC GEO Mus musculus GSE68195 29,614
YY1 mESC KO GEO Mus musculus GSE140546 49,403
YY1 mESC GEO Mus musculus GSE31785 26,881
YY1 mESC GEO Mus musculus GSE99518 11,903
YY1 pro-B-cell GEO Mus musculus GSE73531 10,243
YY1 spleen GEO Mus musculus GSE73531 1,459
YY1 NPC ES-derived GEO Mus musculus GSE25197 7,574
YY1 cortical-neuron 6h-KCL GEO Mus musculus GSE128182 47,180
YY1 cortical-neuron GEO Mus musculus GSE128182 35,236
YY1 pro-B-cell Rag-neg-neg GEO Mus musculus GSE40822 2,107
YY1 mESC CDK7i GEO Mus musculus GSE68195 69,288
YY1 mESC shExos3 GEO Mus musculus GSE68195 39,206
YY1 mESC Rel-30 GEO Mus musculus GSE68195 45,865
YY1 mESC DRB GEO Mus musculus GSE68195 23,851
YY1 mESC Tript GEO Mus musculus GSE68195 67,604
YY1 C2C12 ab GEO Mus musculus GSE45875 2,147
YY1 C2C12 myotube GEO Mus musculus GSE45875 1,012
YY1 C2C12 Linc-YY1 GEO Mus musculus GSE74049 5,949
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks