ZBTB17
Information ZBTB17
- Description
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity). {ECO:0000250|UniProtKB:Q13105, ECO:0000269|PubMed:14560010, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:21258009}.(Source UnitProtKB).
- Full Name
zinc finger and BTB domain containing 17
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 11
- Biotypes
- 6
- Peaks
- 174,982
- Non-redundant peaks
- 116,391
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 22642
- Official Gene Name
- Zbtb17
- JASPAR
- MGI
- MGI:107410
- Ensembl
- ENSMUSG00000006215
- UniProt
- Q60821
- Genevisible
- Q60821
- RefSeq
- NM_009541
- Aliases
- AA589413; Lp-1; Miz1; Zfp100; mZ13
Datasets Table for ZBTB17
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ZBTB17 | pancreas | GEO | Mus musculus | GSE44672 | 1,245 | |||
| ZBTB17 | lymphocyte | Dox | GEO | Mus musculus | GSE44672 | 21,591 | ||
| ZBTB17 | lymphocyte | GEO | Mus musculus | GSE44672 | 24,168 | |||
| ZBTB17 | thymic-lymphoma | P6D4 | GEO | Mus musculus | GSE57694 | 1,501 | ||
| ZBTB17 | tumorspheres | GEO | Mus musculus | GSE64425 | 9,186 | |||
| ZBTB17 | medulloblastoma | GEO | Mus musculus | GSE64425 | 46,512 | |||
| ZBTB17 | thymic-lymphoma | 70Z3 | GEO | Mus musculus | GSE57694 | 14,063 | ||
| ZBTB17 | MEF | 3T9MycER | GEO | Mus musculus | GSE98419 | 2,046 | ||
| ZBTB17 | MEF | Bcells | GEO | Mus musculus | GSE98419 | 14,150 | ||
| ZBTB17 | MEF | GEO | Mus musculus | GSE44672 | 26,927 | |||
| ZBTB17 | tumorspheres | SHH | GEO | Mus musculus | GSE64425 | 13,593 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |