ZBTB33

Information ZBTB33

Description

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

Full Name

zinc finger and BTB domain containing 33

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
12
Biotypes
8
Peaks
175,250
Non-redundant peaks
137,452

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
C2H2 zinc finger factors
Familly
Other factors with up to three adjacent zinc fingers
Sub Familly
Factors with 2-3 adjacent zinc fingersand a BTB/POZ domain

Source TFClass

External IDs

NCBI Gene
10009
Official Gene Name
ZBTB33
JASPAR
MA0527
Ensembl
ENSG00000177485
UniProt
Q86T24
Genevisible
Q86T24
RefSeq
NM_001184742
Aliases
KAISO; WUGSC:H_DJ525N14.1; ZNF-kaiso; ZNF348; kaiso
All peaks ZBTB33
Download BED file
Non redundant peaks ZBTB33
Download BED file
SEQUENCES ZBTB33
Download FASTA file
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Datasets Table for ZBTB33

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ZBTB33 SK-N-SH ENCODE Homo sapiens ENCSR000BTS 9,032
ZBTB33 MCF-7 ENCODE Homo sapiens ENCSR231YFE 10,938
ZBTB33 K-562 ENCODE Homo sapiens ENCSR000BKF 2,242
ZBTB33 K-562 ENCODE Homo sapiens ENCSR876GXA 77,202
ZBTB33 Hep-G2 ENCODE Homo sapiens ENCSR000BNA 2,494
ZBTB33 Hep-G2 ENCODE Homo sapiens ENCSR000BHR 1,988
ZBTB33 A-549 ENCODE Homo sapiens ENCSR000BPZ 13,162
ZBTB33 liver ENCODE Homo sapiens ENCSR345YWJ 4,571
ZBTB33 liver ENCODE Homo sapiens ENCSR516HUP 26,874
ZBTB33 GM12878 ENCODE Homo sapiens ENCSR542FLV 13,736
ZBTB33 GM12878 ENCODE Homo sapiens ENCSR000BHC 6,178
ZBTB33 HCT-116 ENCODE Homo sapiens ENCSR000BNY 6,833
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks