ZBTB7B

Information ZBTB7B

Description

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner (PubMed:15729333, PubMed:29420538). Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision (PubMed:15729333, PubMed:24880459, PubMed:18258917, PubMed:23481257). Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate (PubMed:24880459). During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci (PubMed:22730529). Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells (PubMed:23105140). Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (PubMed:29420538). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:7937772). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation (PubMed:28784777). Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (PubMed:28784777). {ECO:0000269|PubMed:15729333, ECO:0000269|PubMed:18258917, ECO:0000269|PubMed:22730529, ECO:0000269|PubMed:23105140, ECO:0000269|PubMed:23481257, ECO:0000269|PubMed:24880459, ECO:0000269|PubMed:28784777, ECO:0000269|PubMed:29420538, ECO:0000269|PubMed:7937772}.(Source UnitProtKB).

Full Name

zinc finger and BTB domain containing 7B

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
39,521
Non-redundant peaks
39,061

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
22724
Official Gene Name
Zbtb7b
JASPAR
MGI
MGI:102755
Ensembl
ENSMUSG00000028042
UniProt
Q64321
Genevisible
Q64321
RefSeq
NM_009565
Aliases
Thpok; Zfp67; c-Krox
All peaks ZBTB7B
Download BED file
Non redundant peaks ZBTB7B
Download BED file
SEQUENCES ZBTB7B
Download FASTA file
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Datasets Table for ZBTB7B

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ZBTB7B Th1 GEO Mus musculus GSE142069 1,859
ZBTB7B CD4-pos GEO Mus musculus GSE116506 37,662
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks