ZFP281
Information ZFP281
- Description
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000269|PubMed:18757296, ECO:0000269|PubMed:21915945, ECO:0000269|PubMed:22988117}.(Source UnitProtKB).
- Full Name
zinc finger protein 281
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 2
- Peaks
- 94,208
- Non-redundant peaks
- 44,261
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 226442
- Official Gene Name
- Zfp281
- JASPAR
- MGI
- MGI:3029290
- Ensembl
- ENSMUSG00000041483
- UniProt
- Q99LI5
- Genevisible
- Q99LI5
- RefSeq
- NM_177643
- Aliases
Datasets Table for ZFP281
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ZFP281 | mESC | GEO | Mus musculus | GSE131014 | 21,838 | |||
| ZFP281 | EpiSC | OEC2 | GEO | Mus musculus | GSE93042 | 13,972 | ||
| ZFP281 | mESC | GEO | Mus musculus | GSE81042 | 20,997 | |||
| ZFP281 | mESC | 32h | GEO | Mus musculus | GSE131014 | 37,401 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |