ZFP57

Information ZFP57

Description

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:15070898, PubMed:18854139, PubMed:23059534, PubMed:30602440). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (PubMed:15070898, PubMed:18854139, PubMed:23059534). {ECO:0000269|PubMed:15070898, ECO:0000269|PubMed:18854139, ECO:0000269|PubMed:23059534, ECO:0000269|PubMed:30602440}.(Source UnitProtKB).

Full Name

zinc finger protein 57

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
1
Peaks
2,221
Non-redundant peaks
2,141

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
22715
Official Gene Name
Zfp57
JASPAR
MGI
MGI:99204
Ensembl
ENSMUSG00000036036
UniProt
Q8C6P8
Genevisible
Q8C6P8
RefSeq
NM_001168502
Aliases
G19; Zfp-57
All peaks ZFP57
Download BED file
Non redundant peaks ZFP57
Download BED file
SEQUENCES ZFP57
Download FASTA file
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Datasets Table for ZFP57

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ZFP57 mESC GEO Mus musculus GSE123942 1,985
ZFP57 mESC KO GEO Mus musculus GSE123942 136
ZFP57 mESC GEO Mus musculus GSE77440 100
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks