ZIC2

Information ZIC2

Description

Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. {ECO:0000269|PubMed:10677508, ECO:0000269|PubMed:11053430, ECO:0000269|PubMed:11756505, ECO:0000269|PubMed:13678579, ECO:0000269|PubMed:15207726, ECO:0000269|PubMed:15465018, ECO:0000269|PubMed:18417618, ECO:0000269|PubMed:18524895, ECO:0000269|PubMed:20676059}.

Full Name

zinc finger protein of the cerebellum 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
5
Biotypes
1
Peaks
129,320
Non-redundant peaks
55,714

TF Classification

Familly
C2H2 zinc finger factors
Sub Familly
More than 3 adjacent zinc fingers::More than 3 adjacent zinc fingers

Source JASPAR

External IDs

NCBI Gene
22772
Official Gene Name
Zic2
JASPAR
MA1629.1
MGI
MGI:106679
Ensembl
ENSMUSG00000061524
UniProt
Q62520
Genevisible
Q62520
RefSeq
NM_009574
Aliases
GENA 29; HPE5; Ku; odd-paired homolog
All peaks ZIC2
Download BED file
Non redundant peaks ZIC2
Download BED file
SEQUENCES ZIC2
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for ZIC2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ZIC2 mESC GEO Mus musculus GSE131014 22,445
ZIC2 mESC Zfp281-KO GEO Mus musculus GSE131014 11,729
ZIC2 mESC 32h GEO Mus musculus GSE131014 36,524
ZIC2 mESC GEO Mus musculus GSE61188 30,780
ZIC2 mESC Zfp281-KO_32h GEO Mus musculus GSE131014 27,842
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks