ZIC2
Information ZIC2
- Description
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. {ECO:0000269|PubMed:10677508, ECO:0000269|PubMed:11053430, ECO:0000269|PubMed:11756505, ECO:0000269|PubMed:13678579, ECO:0000269|PubMed:15207726, ECO:0000269|PubMed:15465018, ECO:0000269|PubMed:18417618, ECO:0000269|PubMed:18524895, ECO:0000269|PubMed:20676059}.
- Full Name
zinc finger protein of the cerebellum 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 1
- Peaks
- 129,320
- Non-redundant peaks
- 55,714
TF Classification
- Familly
- C2H2 zinc finger factors
- Sub Familly
- More than 3 adjacent zinc fingers::More than 3 adjacent zinc fingers
Source JASPAR
External IDs
- NCBI Gene
- 22772
- Official Gene Name
- Zic2
- JASPAR
- MA1629.1
- MGI
- MGI:106679
- Ensembl
- ENSMUSG00000061524
- UniProt
- Q62520
- Genevisible
- Q62520
- RefSeq
- NM_009574
- Aliases
- GENA 29; HPE5; Ku; odd-paired homolog
Datasets Table for ZIC2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ZIC2 | mESC | GEO | Mus musculus | GSE131014 | 22,445 | |||
| ZIC2 | mESC | Zfp281-KO | GEO | Mus musculus | GSE131014 | 11,729 | ||
| ZIC2 | mESC | 32h | GEO | Mus musculus | GSE131014 | 36,524 | ||
| ZIC2 | mESC | GEO | Mus musculus | GSE61188 | 30,780 | |||
| ZIC2 | mESC | Zfp281-KO_32h | GEO | Mus musculus | GSE131014 | 27,842 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |