msl-1

The gene male-specific lethal 1 is referred to in FlyBase by the symbol Dmelmsl-1 (CG10385, FBgn0005617). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2L:18683720..18688800. Its molecular function is described by: transcription regulatory region sequence-specific DNA binding; protein binding; ubiquitin protein ligase binding; chromatin binding; DNA binding. It is involved in the biological process described with: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome; dosage compensation; histone H4-K16 acetylation; negative regulation of chromatin silencing; dosage compensation by hyperactivation of X chromosome. 58 alleles are reported. The phenotypes of these alleles manifest in: mesothoracic tergum; trichogen cell. The phenotypic classes of alleles include: increased mortality during development; increased mortality; lethal; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

male-specific lethal 1

Source FlyBase

Drosophila melanogaster [tax_id: 7227]

dm6